You need to configure the following to handle a large number of transactions. 

For information on how to deploy clustering, refer to Clustering Deployment Guide.
For information on how to enable JDO caching, refer to Enabling Caching.
For information on how to set correct logging level, refer to Configure Logging Level.

If Adeptia Suite is installed on Windows operating system then you should optimize TCP settings to avoid port exhaustion. For more information, refer to http://msdn.microsoft.com/en-us/library/aa560610(v=bts.20).aspx.